| May | Opponent | Time | |
| Wed 23 | @ Baltimore Oriole Park At Camden Yards, Baltimore, MD | 12:35pm |  |
| Fri 25 | vs Saint Petersburg Fenway Park, Boston, MA | 07:10pm |  |
| Sat 26 | vs Saint Petersburg Fenway Park, Boston, MA | 07:15pm |  |
| Sun 27 | vs Saint Petersburg Fenway Park, Boston, MA | 01:35pm |  |
| Mon 28 | vs Detroit Fenway Park, Boston, MA | 01:35pm |  |
| Tue 29 | vs Detroit Fenway Park, Boston, MA | 07:10pm |  |
| Wed 30 | vs Detroit Fenway Park, Boston, MA | 07:10pm |  |
| Thu 31 | vs Detroit Fenway Park, Boston, MA | 07:10pm |  |
| June | Opponent | Time | |
| Fri 01 | @ Toronto Rogers Centre, Toronto, ON, Canada | 07:07pm |  |
| Sat 02 | @ Toronto Rogers Centre, Toronto, ON, Canada | 01:07pm |  |
| Sun 03 | @ Toronto Rogers Centre, Toronto, ON, Canada | 01:07pm |  |
| Tue 05 | vs Baltimore Fenway Park, Boston, MA | 07:10pm |  |
| Wed 06 | vs Baltimore Fenway Park, Boston, MA | 07:10pm |  |
| Thu 07 | vs Baltimore Fenway Park, Boston, MA | 07:10pm |  |
| Fri 08 | vs Washington Fenway Park, Boston, MA | 07:10pm |  |
| Sat 09 | vs Washington Fenway Park, Boston, MA | 04:05pm |  |
| Sun 10 | vs Washington Fenway Park, Boston, MA | 01:35pm |  |
| Mon 11 | @ Miami Marlins Ballpark, Miami, FL | 07:10pm |  |
| Tue 12 | @ Miami Marlins Ballpark, Miami, FL | 07:10pm |  |
| Wed 13 | @ Miami Marlins Ballpark, Miami, FL | 07:10pm |  |
| Fri 15 | @ Chicago Wrigley Field, Chicago, IL | 01:20pm |  |
| Sat 16 | @ Chicago Wrigley Field, Chicago, IL | 06:15pm |  |
| Sun 17 | @ Chicago Wrigley Field, Chicago, IL | 07:00pm |  |
| Tue 19 | vs Miami Marlins Fenway Park, Boston, MA | 07:10pm |  |
| Wed 20 | vs Miami Marlins Fenway Park, Boston, MA | 07:10pm |  |
| Thu 21 | vs Miami Marlins Fenway Park, Boston, MA | 07:10pm |  |
| Fri 22 | vs Atlanta Fenway Park, Boston, MA | 07:10pm |  |
| Sat 23 | vs Atlanta Fenway Park, Boston, MA | 07:15pm |  |
| Sun 24 | vs Atlanta Fenway Park, Boston, MA | 01:35pm |  |
| Mon 25 | vs Toronto Fenway Park, Boston, MA | 07:10pm |  |