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Did You Know?

Similarly, the half-life of norfluoxetine is longer (16 days) after long-term use. Therefore, the concentration of the drug and its active metabolite in the blood continues to grow through the first few weeks of treatment, and their steady concentration in the blood is achieved only after four weeks. Moreover, the brain concentration of fluoxetine and its metabolites keeps increasing through at least the first five weeks of treatment. That means that the full benefits of the current dose a patient receives are not realized for at least a month since its initiation.

The injection with 0.7 mg/kg fluoxetine corresponds to the standard therapeutic dose of luoxetine, see Similarly, in electrophysiological studies only larger and not smaller doses of fluoxetine changed the activity of rat's norepineprinergic neurons.

Wesbecker had been taking the selective serotonin reuptake inhibitor (SSRI) antidepressant fluoxetine for four weeks before these homicides, and this led to a legal action against the makers of fluoxetine, Eli Lilly.Healy D (2004) Let them eat Prozac.

The injection with 0.7 mg/kg fluoxetine corresponds to the standard therapeutic dose of luoxetine, see Similarly, in electrophysiological studies only larger and not smaller doses of fluoxetine changed the activity of rat's norepineprinergic neurons.

Only one metabolite of fluoxetine, norfluoxetine (demethylated fluoxetine), is biologically active.The extremely slow elimination of fluoxetine and its active metabolite norfluoxetine from the body distinguishes it from other antidepressants.

Subsequent legal cases have further raised the possibility of a link between antidepressant use and violence. Antidepressants and Violence: Problems at the Interface of Medicine and Law, David Healy, Andrew Herxheimer, and David B.Menkes, PLoS Med 3(9): e372 doi:10.1371/journal.pmed.0030372, 2006A meta-analysis published in February 2008 combined 35 clinical trials of four newer antidepressants (fluoxetine, paroxetine (Paxil), nefazodone (Serzone) and venlafaxine (Effexor)).