Pronto Schedule

Upcomming Pronto Events:

• Pronto&Puss N Boots tickets in New York, NY at Mercury Lounge on Thursday March 19, 2009.

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Pronto bio:

The Prontosil was the first commercially exploitable antibacterial drug, developed in 1935 by Gerhard Domagk. Dyes nitrogen, by one to a but on of German Bayer which was then part of IG Farben. The demonstration of its effectiveness against certain bacterial infections of mice would assert to Gerhard Domagk, Nobel Prize in Physiology or medicine in 1939.La the discovery of this first sulfonamide drug opened a new course in medicinal chemistry. Sulfamidochrysoïdine, sodium salt, soluble in water and which gives a solution of a bordeaux red, had first been synthesized by Josef Klarer and Fritz Mietzsch, chemists at Bayer. The first compelling result of the efficiency of the sulfamidochrysoïdine was obtained, at the end of December, 1931, on a systemic infection with Streptococcus (Streptococcus pyogenes) rat. Clinical trials became from 1932 to 1934, first to the nearby hospital of Wuppertal-Elberfeld, led by Philipp Klee, then to the Hospital of the University of Düsseldorf. Published in the issue dated February 15, 1935, the largest German journal of medical sciences of the time, the results were initially received with skepticism by a scientific community particularly careful immunotherapy in General, and in particular vaccination. Leonard Colebrook was the first to use it, in the treatment of puerperal fever. The news of clinical success spread in Europe and, after the healing of Delano Roosevelt, a son of President Franklin D.Roosevelt, interest grew sharply. Dozens of teams of chemists then began to work on the Prontosil. At the end of 1935, in the laboratory of medicinal chemistry led by Ernest furnace the Pasteur Institute, Jacques and Thérèse Tréfouël, Federico Nitti and Daniel Bovet established that the sulfamidochrysoïdine metabolizes in para-aminophénylsulfamide, colourless and simpler than the Prontosil molecule, and they showed that this 1162 F was the active agent of the drug. Renamed Prontosil album in Germany, p-aminophénylsulfamide became the first manageable sulfonamide drugs orally of the firm Bayer. From 1937, it was sold in France under the name of Septoplix by Theraplix institutions, responsible for the marketing of the products of the company Rhône-Poulenc. Sulfamide was cheap, it easily joined other molecules, and he was free of rights: Paul Gelmo, a student in chemistry at the University of Vienna, had done the synthesis in 1909, but without guessing its therapeutic properties.

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